Heat and Cold – complications of storage of EpiPens, Jext and Anapen injectors

I am getting an increasing number of worried enquiries about how best to store adrenaline injectors in warm or cold climates.  Does heat and cold make our Epipens, Jext and Anapen injectors inactive and potentially life threatening?

The manufacturers do have guidelines but they are fairly useless for the real world.

EpiPen say “You should take your EpiPen Auto-Injector everywhere you go, but it should be kept at room temperature (25°C, 77°F) until the marked expiration date, when it should be replaced” .  Just  how is someone meant to keep their EpiPens at this precise temperature and surely a range of temperatures would be more helpful.  In their advice to professionals (not patients) it says:

“EpiPen and EpiPen Jr Auto-Injectors should be stored in the carrier tube provided at a temperature of 25ºC (77ºF); however, temperature excursions between 15ºC and 30ºC (59ºF to 86ºF) are permitted.”

Just what is a temperature “excursion” and how long does an excursion last?  Suppose the safe temperature is exceeded?  Are patients never allowed to go to the beach or play in the snow and just how are patients expected to maintain this temperature range?

Finally, why is the advice to professionals different to advice to patients?

David I Glaser